A train has derailed on the road at Kooragang Island on Friday afternoon.
Traffic on Cormorant Road is backed up to the Stockton Bridge.
Motorists should expect significant delays for several hours and avoid the area.
Eastbound traffic is moving slowly, with a diversion on Egret St and Teal St.
The road is completely closed to westbound traffic, though it's hoped a diversion could open soon.