A motorcyclist has died after being struck by a truck on the Hunter Expressway at Cameron Park overnight.
Police and emergency services were called to the eastbound lanes of the expressway about 3 kilometres east of John Renshaw Drive just before 11pm on Monday.
Early reports suggest the male motorbike rider had fallen from his machine and the truck driver was unable to avoid colliding with him.
The Expressway was closed overnight but has now been re-opened.
The truck driver was not injured and police say they are treating the incident as a freak accident.
Earlier on Monday a 47-year-old man died when his Ford Falcon left the New England Highway at East Maitland - crashing through a fence and landing in Wallis Creek.
The accident happened just before 10am.
The latest fatalities take the Hunter's road toll for 2016 to 43.