Fire crews from Cessnock. Bellbird, Kearsley and Paxton were called to the brick and tile home in Alkira Avenue at 11.45 last night, arriving to find the house well alight.
Newcastle Fire Command says a resident of the home managed to escape without injury.
It took firefighters about an hour to bring the blaze under control and more than four hours to fully extinguish and mop up the fire.
Fire investigators are working to determine how the cause of the fire.