Fire crews are battling a major blaze at Murray's Brewery at Bobs Farm.
Around 30 RFS and NSW Fire and Rescue crews were called to the well-known business on Nelson Bay Road just before 6.00am to find a fire in kitchen area of a detached residence.
Newcastle Fire and rescue says the roof of the building has collapsed
The RFS says the fire has caused major damage but the brewery operations have not been affected by the fire.
