The New England Highway is closed in both directions after two semi-trailers collided north of Scone.
The nose-to-tail crash occurred just after 3 o'clock this morning (Wednesday 5 December) about 1 kilometre south of Parkville.
The Hunter's Westpac Rescue Helicopter says the 45-year-old driver of one of the trucks was trapped before being released - he was treated at the scene before being taken by ambulance to Scone Airport and flown to the John Hunter Hospital in a serious but stable condition with suspected spinal and pelvic injuries and a broken shoulder blade.
At least one of the trucks lost it's load of mixed goods in the crash.
A Fire and Rescue unit from Scone and the Hazmat unit from Tamworth are at the scene.
The highway is likely to remain closed for some hours while the road is cleared, with diversions in place.
