A refrigerated truck overturned in the northbound lanes under the Freemans Drive Overpass just after 4.30.
The truck then burst into flames which has also started a bushfire next to the motorway.
Police say the driver has managed to escape with only minor injuries.
The northbound lanes of the M1 are blocked with diversions in place at Freemans Drive and Palmers Road.
More than a dozen Fire & Rescue firefighters are at the scene along with the Rural Fire Service.
The northbound lanes of the motorway are expected to be closed for several hours.
